β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-
Pseduoprotodioscin
CAS: 102115-79-7
Molecular Formula: C51H82O21
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- - Names and Identifiers
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- - Physico-chemical Properties
| Molecular Formula | C51H82O21 |
| Molar Mass | 1031.18 |
| Density | 1.45 |
| Melting Point | >201°C (dec.) |
| Specific Rotation(α) | -80.4 (c, 1 in Py) |
| Solubility | Soluble in methanol, slightly soluble in water |
| Appearance | White powder |
| Color | Off-White to Pale Yellow |
| pKa | 12?+-.0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD04039839 |
| Physical and Chemical Properties | White crystal, soluble in methanol and water, insoluble in acetone and ethyl acetate, derived from yellow yam, Dioscorea zingiberensis and Dioscorea zingiberensis. |
| In vitro study | In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels. |
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- - Reference
| Reference Show more | 1. Geke Gao, Yuming Cui, et al. Simultaneous determination of 11 kinds of saponins in Yunnan Paridis by UPLC [J]. Journal of Pharmaceutical Analysis, 2017, 037(009):1572-1577. 2. Ma Jingqian, Cui Naiyan, Yu River, Li Zheng, Liu Erwei, Bisong Tao. Evaluation of effects of drying methods on effective components of Dioscorea composita based on quantitative analysis of four saponins [J]. Central South pharmacy, 2021,19(03):413-418. 3. [IF = 2.289] Zhou Shun et al."Anthelmintic effect of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and IR 3D-QSAR analysis." Parasitol Res. 2021 Mar;120(3):1143-1150 |
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- - Reference Information
| Application | pseudo-original dioscin has anti-hypoxia effect, which can be used for content determination/identification/pharmacological experiments, etc, can be used for cardiovascular disease. |
| biological activity | pseudo protocicin, a glucoside of furan that inhibits SREBP1/2 and microRNA 33a/B levels, reduces the expression of genes involved in cholesterol and triglyceride synthesis. |
| Use | pseudo-original dioscin has anti-hypoxia effect. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: for cardiovascular disease |
Last Update：2024-04-09 21:00:56
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